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Catalog Number:
300-03
Synonyms:
Granulocyte-Macrophage Colony-Stimulating Factor, CSF-2, MGI-1GM, Pluripoietin-α
GM-CSF是，刺激中性粒細(xì)胞和巨噬細(xì)胞的發(fā)展造血生長因子，并促進(jìn)早期紅細(xì)胞巨核細(xì)胞和嗜酸性祖細(xì)胞的增殖和發(fā)展。它產(chǎn)生于血管內(nèi)皮細(xì)胞，單核細(xì)胞，成纖維細(xì)胞和T-淋巴細(xì)胞。GM-CSF抑制中性粒細(xì)胞遷移和增強(qiáng)了成熟的zui終細(xì)胞的功能活性。人和鼠分子是物種特異性，并表現(xiàn)出無交叉物種反應(yīng)性。重組人GM-CSF是14.6 kDa的球狀蛋白包含128個氨基酸，含有兩個分子內(nèi)二硫鍵和兩個潛在的N-聯(lián)糖基化位點(diǎn)。
Description:
GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages, and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant Human GM-CSF is a 14.6 kDa globular protein consisting of 128 amino acids, containing two intramolecular disulfide bonds and two potential N-linked glycosylation sites.
AA Sequence:
MAPARSPSPS TQPWEHVNAI QEARRLLNLS RDTAAEMNET VEVISEMFDL QEPTCLQTRL ELYKQGLRGS LTKLKGPLTM MASHYKQHCP PTPETSCATQ IITFESFKEN LKDFLLVIPF DCWEPVQE
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.
Cross Reactivity:
Human, Bacteria, Mouse, Leech, Pig, Human + Mouse
Animal Free Recombinant Protein AF-300-03 AF-300-03-20 Human GM-CSF 20ug Standard
Animal Free Recombinant Protein AF-300-03 AF-300-03-50 Human GM-CSF 50ug Bulk
Animal Free Recombinant Protein AF-300-03 AF-300-03-100 Human GM-CSF 100ug Bulk
Animal Free Recombinant Protein AF-300-03 AF-300-03-250 Human GM-CSF 250ug Bulk
Animal Free Recombinant Protein AF-300-03 AF-300-03-500 Human GM-CSF 500ug Bulk
Animal Free Recombinant Protein AF-300-03 AF-300-03-1000 Human GM-CSF 1000ug Bulk