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| 品牌 | StemRD/美國 |
|---|
產(chǎn)品信息
Wnt信號(hào)通路是一個(gè)復(fù)雜的蛋白質(zhì)作用網(wǎng)絡(luò)，其功能zui常見于胚胎發(fā)育和癌癥，但也參與成年動(dòng)物的正常生理過程。Wnt信號(hào)通路包括許多可調(diào)控Wnt信號(hào)分子合成的蛋白質(zhì)，它們與靶細(xì)胞上的受體相互作用，而靶細(xì)胞的生理反應(yīng)則來源于細(xì)胞和胞外Wnt配體的相互作用。
CHIR99021 (CT99021)
is a glycogen synthase kinase 3β (GSK3β) inhibitor with IC50 less than 10 nM. Compared to other GSK-3 inhibitors, CHIR-99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) with 350-fold selectivity toward GSK-3β compared to CDKs .
Ref: Tighe A et al. BMC Cell Biol. 2007 Aug 14;8:3
Purity:
Greater than 99% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
Biological Activity:
In a cell-based assay measuring the activation of the TCF reporter gene, this compound gives EC50 of 50 nM.
重慶市華雅干細(xì)胞技術(shù)有限公司